Biosketch: Teiichi Furuichi
​古市貞一

     My current research interests are in (1) studying the molecular mechanisms of brain development

and its disorders and (2) attempting to systematize the transcriptomic basis underlying the postnatal

development of mouse cerebellum.

 

     We now focus on the study of synapses and circuits by analyzing function and expression of

several brain development-related genes including CAPS2/Cadps2 (a dense-core vesicle secretion

-related protein that promotes BDNF secretion kinetics and is thought to be associated with autism

susceptibility), very-KIND/Kndc1 (a MAP2-binding RasGEF that regulates dendrite growth), Cupidin/Homer2 (a postsynaptic scaffold protein that regulates morphology of postsynapses via interacting with actin cytoskeleton regulators Drebrin and Cdc42), p130Cas/Bcar1 (an adaptor protein that links the Src protein tyrosine kinase signaling and the actin cytoskeleton signaling to regulate growth cone extension), Opalin/Tmem10 (a sialylglyco-transmembrane protein localized in the paranodal loop membrane of the mammalian CNS myelin), phospholipase D 4 (PLD4, an atypical PLD family member expressed in microglia), and LAMP5 (lysosomal associated membrane protein family member 5).

 

     I acts as the project leader of the Brain Transcriptome Database, BrainTx (previous name: Cerebellar Development Transcriptome Database, CDT-DB) (http://www.cdtdb.neuroinf.jp) that is a neuroinformatics database containing a large amount of the information regarding the spatiotemporal expression patterns of genes involved in the postnatal development of mouse cerebellum and is supported by the RIKEN Neuroinformatics Japan Center (NIJC), Japan Node of the International Neuroinformatics Coordination Facility (INCF).

 

 

Research experience

Adjunct Professor, Tokyo University of Science (2021-present)

Professor, Tokyo University of Science (2011-2020)

Part-time Team Leader, RIKEN Brain Science Institute (2011)

Laboratory Head, RIKEN Brain Science Institute (1999-2010)

Visiting Professor, Saitama University Brain Science Institute (2009-2010)

Visiting Professor, Hiroshima University Graduate School of Biomedical Sciences (2009-2010)

Associate Professor, Institute of Medical Science, University of Tokyo (1992-1998)

Research Associate, National Institute for Basic Biology (1989-1991)

Postdoctoral Fellow, National Institute for Basic Biology (1986-1988)

Postdoctoral Fellow, State University of New York at Stony Brook (1986)

 

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PUBLICATION LIST

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Original publications​​

1. Iguchi H, Katsuzawa T, Saruta C, Sadakata T, Kobayashi S, Sato Y, Sato A, Sano Y, Maezawa S, Shinoda Y, Furuichi T. Calcium-dependent activator protein for secretion 2 is involved in dopamine release in mouse midbrain neurons. Frontiers in Molecular Neuroscience 17:1444629, 2024.

2. Takahashi J, Yamada D, Nagano W, Sano Y, Furuichi T, Saitoh A. Oxytocinergic projection from the hypothalamus to supramammillary nucleus drives recognition memory in mice. PLoS One 18(11):e0294113, 2023.

3. Tsuruda Y, Akita S, Yamanaka K, Yamamoto M, Sano Y, Furuichi T, Takemura H. Markerless 3D Pose Estimation System for Mouse Musculoskeletal Model Using DeepLabCut and Multiple RGB-D Cameras. 2023 IEEE/SICE International Symposium on System Integration (SII) 1-6, 2023.

4. Oikawa H, Tsuruda Y, Sano Y, Furuichi T, Yamamoto M, Takemura H. Deep-Learning Approach for Revealing Latent Behaviors in Mice: Development of Walking Trajectories Prediction Model and Applications. 2023 IEEE International Conference on Systems, Man, and Cybernetics (SMC) 5114-5119, 2023.

5. Sato Y, Tsuyusaki M, Takahashi-Iwanaga H, Fujisawa R, Masamune A, Hamada S, Matsumoto R, Tanaka Y, Kakuta Y, Yamaguchi-Kabata Y, Furuse T, Wakana S, Shimura T, Kobayashi R, Shinoda Y, Goitsuka R, Maezawa S, Sadakata T, Sano Y, and Furuichi T. Loss of CAPS2/Cadps2 leads to exocrine pancreatic cell injury and intracellular accumulation of secretory granules in mice. Frontiers in Molecular Biosciences 9:1040237, 2022.

6. Sakamoto Y, Ishimoto A, Sakai Y, Sato M, Nishihama R, Abe K, Sano Y, Furuichi T, Tsuji H, Kohchi T, Matsunaga S. Improved clearing method contributes to deep imaging of plant organs. Communications Biology 5(1):12, 2022.

7. Tsuruda Y, Akita S, Yamanaka K, Yamamoto M, Sano Y, Furuichi T, Takemura H. 3D body parts tracking of mouse based on RGB-D under an open field. Annu. Int. Conf. IEEE Eng. Med. Biol. Soc. 7252-7255, 2021.

8. Furuichi T, Muto Y, Sadakata T, Sato Y, Hayashi K, Shiraishi-Yamaguchi Y, Shinoda Y. The physiological role of Homer2a and its novel short isoform, Homer2e, in NMDA receptor-mediated apoptosis in cerebellar granule cells. Molecular Brain 14(1) 2021.

9. Wada M, Takano K, Ide M, Sano Y, Shinoda Y, Furuichi T and Kansaku K.Task-Related c-Fos Expression in the Posterior Parietal Cortex During the “Rubber Tail Task” Is Diminished in Ca2+-Dependent Activator Protein for Secretion 2 (Caps2)-Knockout Mice. Front. Behav. Neurosci. 15:680206, 2021.

10. Fujima S, Yamaga R, Minami H, Mizuno S, Shinoda Y, Sadakata T, Abe M, Sakimura K, Sano Y, and Furuichi T. CAPS2 deficiency impairs the release of the social peptide, oxytocin, as well as oxytocin-associated social behavior. Journal of Neuroscience. 41(20):4524-4535, 2021.

11. Ishii C, Shibano N, Yamazaki M, Arima T, Kato Y, Ishii Y, Shinoda Y, Fukazawa Y, Sadakata T, Sano Y, Furuichi T. CAPS1 is involved in hippocampal synaptic plasticity and hippocampus-associated learning. Scientific Reports. 11(1), 2021.

12. Sugimoto H, Horii T, Hirota JN, Sano Y, Shinoda Y, Konno A, Hirai H, Ishizaki Y, Hirase H, Hatada I, Furuichi T, Sadakata T. The Ser19Stop single nucleotide polymorphism (SNP) of human PHYHIPL affects the cerebellum in mice. Mol. Brain 14(1):52, 2021.

13. Mizuno S., Hirota J., Ishii C., Iwasaki H., Sano Y., Furuichi T. Comprehensive profiling of gene expression in the cerebral cortex and striatum of BTBRTF/ArtRbrc mice compared to C57BL/6J mice. Frontiers in Cellular Neuroscience. In press.

14. Fujima S., Amemiya N., Arima T., Sano Y., Furuichi T. CAPS2 deficiency induces proopiomelanocortin accumulation in pituitary and affects food intake behavior in mice. Neuroscience Letters, 738: 135335, 2020.

15. Abe K., Kuroda M., Narumi Y., Kobayashi Y., Itohara S., Furuichi T., Sano Y. Cortico-amygdala interaction determines the insular cortical neurons involved in taste memory retrieval. Molecular Brain, 13:107, 2020.

16. Shibano N., Yamazaki M., Arima T., Abe K., Kuroda M., Kobayashi Y., Itohara S., Furuichi T., Sano Y. Excitation of prefrontal cortical neurons during conditioning enhances fear memory formation. Scientific Reports, 10(1):8613, 2020.

17. Sato Y., Sato A., Mizuno S., Hirota J., Fujima S., Ishii C., Sano Y., and Furuichi T. Comparative gene expression analysis of the engulfment and cell motility (ELMO) protein family in the mouse brain. Gene Expression Patterns, 34, 119070, 2019.

18. Hosoi N., Shibasaki K., Hosono M., Konno A., Shinoda Y., Kiyonari H., Inoue K., Muramatsu S.-i., Ishizaki Y., Hirai H., Furuichi T., Sadakata T. Deletion of class II ADP-ribosylation factors in mice causes tremor by the Nav1.6 loss in cerebellar Purkinje cell axon initial segments. J. Neurosci. 39(32): 6339-6353, 2019.

19. Wada M., Ide M., Atsumi T., Sano Y., Shinoda Y., Furuichi T., Kansaku K. Rubber tail illusion is weakened in Ca2+-dependent activator protein for secretion 2 (Caps2)-knockout mice. Scientific Reports 9(1):7552, 2019.

20. Koebis M., Urata S., Shinoda Y., Okabe S., Yamasoba T., Nakao K., Aiba A., Furuichi T. LAMP5 in presynaptic inhibitory terminals in the hindbrain and spinal cord: a role in startle response and auditory processing. Molecular Brain 12:20, 2019.

21. Shinoda Y., Sadakata T., Yagishita K., Kinameri E., Katoh-Semba R., Sano Y., Furuichi T. Aspects of excitatory/inhibitory synapses in multiple brain regions are correlated with levels of brain-derived neurotrophic factor/neurotrophin-3. Biochem. Biophys. Res. Commun. 509 (2):429-434, 2019.

22. Morita M, Shimokawa K, Nishimura M, Nakamura S, Tsujimura Y, Takemoto S, Tawara T, Yokota H, Wemler S, Miyamoto D, Ikeno H, Sato A, Furuichi T, Kobayashi N, Okumura Y, Yamaguchi Y, Okamura-Oho Y. ViBrism DB: an interactive search and viewer platform for 2D/3D anatomical images of gene expression and co-expression networks. Nucleic Acid Res. 47: Database issue, D859-D866, 2019.

23. Shinoda Y, Sadakata T, Akagi T, Sakamaki Y, Hashikawa T, Sano Y, Furuichi T. Calcium-dependent activator protein for secretion 2 (CADPS2) deficiency causes abnormal synapse development in hippocampal mossy fiber terminals development in hippocampal mossy fiber terminals. Neurosci Lett. 677:65-71, 2018.

24. Nakayama K., Ohashi R., Shinoda Y., Yamazaki M., Abe M., Fujikawa A., Shigenobu S., Futatsugi A., Noda M., Mikoshiba K., Furuichi T., Sakimura K., and Shiina N. RNG105/caprin1, an RNA granule protein for dendritic mRNA localization, is essential for long-term memory formation. eLife 6: e29677, 2017.

25. Yagishita K., Suzuki R., Mizuno S., Katoh-Semba R., Sadakata T., Sano Y., Furuichi T., Shinoda Y. CAPS2 deficiency affects environmental enrichment-induced adult neurogenesis and differentiation/survival of newborn neurons in the hippocampal dentate gyrus. Neuroscience Letters 661:121-125, 2017

26. Ihara D., Fukuchi M., Katakai M., Shinoda Y., Katoh-Semba R., Furuichi T., Ishikawa M., Tabuchi A., Tsuda M. Deltamethrin increases neurite outgrowth in cortical neurons through endogenous BDNF/TrkB pathways. Cell Structure and Function 42(2): 141-148, 2017

27. Hayashi K, Furuya A, Sakamaki Y, Akagi T, Shinoda Y, Sadakata T, Hashikawa T, Shimizu K, Minami H, Sano Y, Nakayama M, and Furuichi T. The brain-specific RasGEF very-KIND is required for normal dendritic growth in cerebellar granule cells and proper motor coordination. PLoS ONE 12(3):e0173175, 2017

28. Sadakata, T., Shinoda, Y., Ishizaki, Y., and Furuichi, T. Analysis of gene expression in Ca2+-dependent activator protein for secretion 2 (Cadps2) knockout cerebellum using GeneChip and KEGG pathways. Neurosci. Lett. 639: 88-93, 2017

29. Yoshikawa, F., Sato, Y., Tohyama, K., Akagi, T., Furuse, T., Sadakata, T., Tanaka, M., Shinoda, Y., Hashikawa, T., Itohara, S., Sano, Y., Ghandour, SM., Wakana, S., and Furuichi, T. Mammalian-specific central myelin protein Opalin is redundant for normal myelination: structural and behavioral assessments. PLoS ONE 11(11): e0166732, 2016

30. Shinoda, Y., Nakajima, Y., Iguchi, H., Tatsumi, S., Kitaoka, M., Nakajima, M., Takahashi, T., Fujiwara, M., and Furuichi, T. Galacto-N-biose is neuroprotective against glutamate-induced excitotoxicity in vitro. Eur. J. Pharmacol. 791: 711-717, 2016

31. Shinoda, Y., Ishii, C., Fukazawa, Y., Sadakata, T., Ishii, Y., Sano, Y., Iwasato, T., Itohara, S., and Furuichi, T. CAPS1 stabilizes the state of readily releasable synaptic vesicles to fusion competence at CA3–CA1 synapses in adult hippocampus. Sci. Rep. 6:31540, 2016

32. Nakajima, Y., Iguchi, H., Kamisuki, S., Sugawara, F., Furuichi, T., Shinoda, Y. Low doses of the mycotoxin citrinin protect cortical neurons against glutamate-induced excitotoxicity. J. Toxicol. Sci., 41:311-319, 2016

33. Hosono, M., Shinoda, Y., Hirano, T., Ishizaki, Y., Furuichi, T., Sadakata, T. Interaction of Ca2+-dependent activator protein for secretion 1 (CAPS1) with septin family proteins in mouse brain. Neurosci. Lett. 617: 232–235, 2016

34. Mishima, Y., Shinoda, Y., Sadakata, T., Kojima, M., Wakana, S., and Furuichi, T. Lack of stress responses to long-term effects of corticosterone in Caps2 knockout mice. Sci. Rep. 5:8932, 2015

35. Okamura-Oho, Y., Shimokawa, K., Nishimura, M., Takemoto, S., Sato, A., Furuichi, T., and Yokota, H. Broad integration of expression maps and co-expression networks compassing novel gene functions in the brain. Sci. Rep. 4:6969, 2014

36. Sato, Y., Yoshikawa, F., Sadakata, T., Shinoda, Y., Koebis, M., and Furuichi, T. Age-dependent redistribution and hypersialylation of the central myelin paranodal loop membrane protein Opalin in the mouse brain. Neurosci. Lett. 581:14-19, 2014

37. Sadakata, T., Kakegawa, W., Shinoda, Y., Hosono, M., Katoh-Semba, R., Sekine, Y., Sato, Y., Saruta, C., Ishizaki, Y., Yuzaki, M., Kojima, M., and Furuichi, T. Axonal localization of Ca2+-dependent activator protein for secretion 2 is critical for subcellular locality of brain-derived neurotrophic factor and neurotrophin-3 release affecting proper development of postnatal mouse cerebellum. PLoS ONE 9(6):e99524, 2014

38. Tanabe, K., Yamazaki, H., Inaguma, Y., Asada, A., Kimura, T., Takahashi, J., Taoka, M., Ohshima T., Furuichi, T., Isobe, T., Nagata, K., Shirao, T., and Hisanaga, S. Phosphorylation of Drebrin by cyclin-dependent kinase 5 and its role in neuronal migration. PLoS ONE 9(3): e92291, 2014

39. Sadakata, T., Kakegawa, W., Shinoda, Y., Hosono, M., Katoh-Semba,R., Sekine, Y., Sato, Y., Tanaka, M., Iwasato, T., Itohara, S., Furuyama, K., Kawaguchi, Y., Ishizaki, Y., Yuzaki, M., and Furuichi, T. CAPS1 deficiency perturbs dense-core vesicle trafficking and Golgi structure and reduces presynaptic release probability in the mouse brain. J. Neurosci., 33:17326-17334, 2013

40. Motoyoshi-Yamashiro, A., Tamura, M., Moriyama, M., Takano, K., Kawabe, K., Nakajima, H., Katoh-Semba, R., Furuichi, T., and Nakamura, Y. Activation of cultured astrocytes by amphotericin B: Stimulation of NO and cytokines production and changes in neurotrophic factors. Neurochem. Int. 63:93-100, 2013.

41. Tanaka, M., Shih, PY., Gomi, H., Yoshida, H., Nakai, J., Ando, R., Furuichi, T., Mikoshiba, K., Semyanov, A., and Itohara, S. Astrocytic Ca2+ signals are required for the functional integrity of tripartite synapses. Mol. Brain 6:6, 2013

42. Sadakata, T., Shinoda, Y., Oka, M., Sekine, Y., and Furuichi, T. Autistic-like behavioral phenotypes in a mouse model with copy number variation of the CAPS2/CADPS2 gene. FEBS Lett. 587:54-59, 2013

43. Sadakata, T., Shinoda, Y., Oka, M., Sekine, Y., Sato, Y., Saruta, C., Miwa, H., Tanaka, M., Itohara, S., and Furuichi, T. Reduced axonal localization of a Caps2 splice variant impairs axonal release of BDNF and causes autistic-like behavior in mice. Proc. Natl. Acad. Sci. U.S.A. 109:21104-21109, 2012

44. Fujita, H., Morita, N., Unno, T., Furuichi, T., and Sugihara, I. Clustered fine compartmentalization of the mouse embryonic cerebellar cortex is rearranged into the postnatal striped organization. J. Neurosci. 32:15688-15703, 2012.

45. Sadakata, T., Sekine, Y., Oka, M., Itakura, M., and Furuichi, T. Calcium-dependent activator protein for secretion 2 interacts with the class II ARF small GTPases and regulates dense-core vesicle trafficking. FEBS J. 279:384-394, 2012

46. Otani, Y., Yamaguchi, Y., Sato, Y., Furuichi, T., Ikenaka, K., Kitani, H., and Baba, H. PLD4 is involved in phagocytosis of microglia: expression and localization changes of PLD4 are correlated with activation state of micrglia. PLoS One 6(11):e27544, 2011.

47. Hamatake, M., Miyazaki, N., Sudo, K., Matsuda, M., Sadakata, T., Furuya, A., Ichisaka, S., Hata, Y., Nakagawa, C., Nagata, K., Furuichi, T., Katoh-Semba, R. Phase advance of the light-dark cycle perturbs diurnal rhythms of brain-derived neurotrophic factor and neurotrophin-3 protein levels, which reduces synaptophysin-positive presynaptic terminals in the cortex of juvenile rats. J. Biol. Chem. 286:21478-21487, 2011

48. Huang, J., Furuya, A., Hayashi, K., and Furuichi, T. Interaction between very-KIND RasGEF and MAP2, and its role in dendrite growth: structure and function of the second kinase non-catalytic C-lobe domain. FEBS J. 278:1651-1661, 2011

49. Shinoda, Y., Sadakata, T., Nakao, K., Katoh-Semba, R., Kinameri, E., Furuya, A., Yanagawa, Y., Hirase, H., and Furuichi, T. Calcium-dependent activator protein for secretion 2 (CAPS2) promotes BDNF secretion and is critical for the development of GABAergic interneuron network. Proc. Natl. Acad. Sci. U.S.A. 108:373-378, 2011

50. Masuya, H., Makita, Y., Kobayashi, N., Nishikata, K., Yoshida, Y., Mochizuki, Y., Doi, K., Takatsuki, T., Waki, K., Tanaka, K., Ishii, M., Matsushima, A., Takahashi, S., Mizoguchi, R., Kozaki, T., Furuichi, T., Kawaji, H., Wakana, S., Nakamura, Y., Yoshiki, A., Murata, T., Fukami-Kobayashi, K., Mohan, S., Ohara, O., Hayashizaki, Y., Obata, Y., and Toyoda, T. The RIKEN integrated database of mammals. Nucleic Acids Res. 39:D861-870, 2011

51. Yoshikawa, F., Banno, Y., Otani, Y., Yamaguchi, Y., Nagakura-Takagi, Y., Morita, N., Sato, Y., Saruta, C., Nishibe, H., Sadakata, T., Shinoda, Y., Hayashi, K., Mishima, Y., Baba, H., and Furuichi, T. Phospholipase D Family Member 4, a Transmembrane Glycoprotein with no Phospholipase D activity, Expression in Spleen and Early Postnatal Microglia. PLoS ONE 5(11):e13932, 2010

52. Sadakata, T., Shinoda, Y., Sekine, Y., Saruta, C., Itakura, M., Takahashi, M., and Furuichi, T. Interaction of CAPS1 with the class II Arf small GTPases is required for dense-core vesicle trafficking in the trans-Golgi network. J. Biol. Chem. 285:38710-38719, 2010

53. Furutama, D., Morita, N., Takano, R., Sekine, Y., Sadakata, T., Shinoda, Y., Hayashi, K., Mishima, Y., Mikoshiba, K., Hawkes, R., and Furuichi, T. Expression of the IP3R1 promoter-driven nls-lacZ transgene in Purkinje cell parasagittal arrays of developing mouse cerebellum. J. Neurosci. Res. 88:2810-2825, 2010

54. Shiraishi-Yamaguchi, Y., Sato, Y., Sakai, R., Mizutani, A., Knopfel, T., Mori, N., Mikoshiba, K., and Furuichi, T. Interaction of Cupidin/Homer2 with two actin cytoskeletal regulators, Cdc42 small GTPase and Drebrin, in dendritic spines. BMC Neurosci. 10(1):25, 2009

55. Amano, K., Fujii, M., Arata, S., Tojima, T., Ogawa, M., Morita, N., Shimohata, A., Furuichi, T., Itohara, S., Kamiguchi, H., Korenberg, J.R., Arata, A., and Yamakawa, K. DSCAM deficiency causes loss of pre-inspiratory neuron synchroneity and perinatal death. J. Neurosci. 29:2984-2996, 2009

56. Yoshikawa, F., Sato, Y., Tohyama, K., Akagi, T., Hashikawa, T., Nagakura-Takagi, Y., Sekine, Y., Morita, N., Baba, H., Suzuki, Y., Sugano, S., Sato, A., and Furuichi, T. Opalin, a transmembrane sialylglycoprotein located in the central nervous system myelin paranodal loop membrane. J. Biol. Chem. 283:20830-20840, 2008

57. Mizutani, A., Kuroda, Y., Futatsugi, A., Furuichi, T., and Mikoshiba, K. Phosphorylation of Homer3 by calcium/calmodulin-dependent kinase II regulates a coupling state of its target molecules in Purkinje cells. J. Neurosci. 28:5369-5382, 2008

58. Suzuki, T., Inoue, I., Yamagata, T., Morita, N., Furuichi, T., and Yamakawa, K. Sequential expression of Efhc1/myoclonin1 in choroid plexus and ependymal cell cilia. Biochem. Biophys. Res. Commun. 367:226-233, 2008

59. Tsutsumi, K., Tomomura, M., Furuichi, T., and Hisanaga, S. Palmitoylation-dependent endosomal localization of AATYK1A and its interaction with Src. Genes to Cells 13:949-964, 2008

60. Hayashi, A., Kasahara, T., Iwamoto, K., Ishiwata, M., Kametani, M., Kakiuchi, C., Furuichi, T., and Kato, T. The role of brain-derived neurotrophic factor (BDNF)-induced XBP1 splicing during brain development. J. Biol. Chem., 282(47): 34525-34534, 2007

61. Huang, J., Furuya, A., and Furuichi, T. Very-KIND, a KIND domain-containing RasGEF, controls dendrite growth by linking Ras small GTPases and MAP2. J. Cell Biol. 179:539-552, 2007

62. Sadakata, T., Kakegawa, W., Mizoguchi, A., Washida, M., Katoh-Semba, R., Shutoh, F., Okamoto, T., Nakashima, H., Kimura, K., Tanaka, M., Sekine, Y., Itohara, S., Yuzaki, M., Nagao, S., and Furuichi, T. Impaired cerebellar development and function in mice lacking CAPS2, a protein involved in neurotrophin release. J. Neurosci. 27:2472-2482, 2007

63. Sadakata, T., Washida, M., Iwayama, Y., Shoji, S., Sato, Y., Ohkura, T., Kato-Semba, R., Nakajima, M., Sekine, Y., Tanaka, M., Nakamura, K., Iwata, Y., Tsuchiya, K.J., Mori, N., Detera-Wadleigh, S.D., Ichikawa, H., Itohara, S., Yoshikawa, T., and Furuichi, T. Autistic-like phenotypes in Cadps2-knockout mice and aberrant CADPS2 splicing in autistic patients. J. Clin. Invest. 117:931-943, 2007

64. Sadakata T, Washida M, and Furuichi T. Alternative splicing variations in mouse CAPS2: differential expression and functional properties of splicing variants. BMC Neurosci. 8:25, 2007

65. Sadakata, T., Washida, M., Morita, N., and Furuichi, T. Tissue distribution of Ca2+-dependent activator protein for secretion family members CAPS1 and CAPS2 in mice. J. Histochem. Cytochem. 55:301-311, 2007

66. Aruga, J., Yoshikawa, F., Nozaki, Y., Sakaki, Y., Toyoda, A., and Furuichi, T. An oligodendrocyte enhancer in a phylogenetically conserved intron region of the mammalian myelin gene Opalin. J. Neurochem. 102:1533-1547, 2007

67. Tomomura, M., Morita, N., Yoshikawa, F., Konishi, A., Akiyama, H., Furuichi, T., and Kamiguchi, H.Structural and functional analysis of the apoptosis-associated tyrosine kinase (AATYK) family. Neurosci. 148:510-521, 2007

68. Ohnishi, T., Ohba, H., Seo, K.C., Im, J., Sato, Y., Iwayama, Y., Furuichi, T., Chung, S.K., and Yoshikawa, T. Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1. J. Biol. Chem. 282:637-646, 2007

69. Ajima, R., Kajiya, K., Inoue, T., Tani, M., Shiraishi-Yamaguchi, Y., Maeda, M., Segawa, T., Furuichi, T., Sutoh, K., and Yokota, J. HOMER2 binds MYO18B and enhances its activity to suppress anchorage independent growth. Biochem. Biophys. Res. Commun. 356:851-856, 2007

70. Ogiwara, I., Miyamoto, H., Morita, N., Atapour, N., Mazaki, E., Inoue, I., Takeuchi, T., Itohara, S., Yanagawa Y., Obata, K., Furuichi, T., Hensch, T.K., and Yamakawa, K. NaV1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation. J. Neurosci. 27:5903-5914, 2007

71. Kuwajima, M., Dehoff, M.H., Furuichi, T., Worley, P.F., Hall, R.A., and Smith, Y. Localization and expression of group I metabotropic glutamate receptors in the mouse striatum, globus pallidus, and subthalamic nucleus: regulatory effects of MPTP treatment and constitutive Homer deletion. J. Neurosci. 27:6249-6260, 2007

72. Huang, J., Sakai, R., and Furuichi, T. The docking protein Cas links tyrosine phosphorylation signaling to elongation of cerebellar granule cell axons. Mol. Biol. Cell. 17:3187-3196, 2006

73. Sadakata, T., Itakura, M., Kozaki, S., Sekine, Y., Takahashi, M., and Furuichi, T. Differential distributions of the Ca2+-dependent activator protein for secretion family proteins (CAPS2 and CAPS1) in the mouse brain. J. Comp. Neurol. 495:735-753, 2006

74. Sadakata, T. and Furuichi, T. Identification and mRNA expression of Ogdh, QP-C, and two predicted genes in the postnatal mouse brain. Neurosci. Lett. 405:217-222, 2006

75. Kawano, S., Otsu, K., Kuruma, A., Shoji, S., Yanagida, E., Muto, Y., Yoshikawa, F., Hirayama, Y., Mikoshiba, K., and Furuichi, T. ATP autocrine/paracrine signaling induces calcium oscillations and NFAT activation in human mesenchymal stem cells. Cell Calcium 39:313-324, 2006

76. Tomomura, M. and Furuichi, T. Apoptosis-associated tyrosine kinase (AATYK) has differential Ca2+-dependent phosphorylation states in response to survival and apoptotic conditions in cerebellar granule cells. J. Biol. Chem. 280:35157-35163, 2005

77. Matsuki, T., Hori, G., and Furuichi, T. Gene expression profiling during the embryonic development of mouse brain using an oligonucleotide-based microarray system. Mol. Brain Res. 136:231-254, 2005

78. Iwai, M., Tateishi, Y., Hattori, M., Mizutani, A., Nakamura, T., Futatsugi, A., Inoue, T., Furuichi, T., Michikawa, T., and Mikoshiba, K. Molecular cloning of mouse type 2 and type 3 inositol 1,4,5-trisphosphate receptors and identification of a novel type 2 receptor splice variant. J. Biol. Chem. 280:10305-10317, 2005

79. Sadakata, T., Mizoguchi, A., Sato, Y., Katoh-Semba, R., Fukuda, M., Mikoshiba, K., and Furuichi, T. The secretory granule-associated protein CAPS2 regulates neurotrophin release and cell survival. J. Neurosci. 24:43-52, 2004

80. Shiraishi, Y., Mizutani, A., Yuasa, S., Mikoshiba, K., and Furuichi, T. Differential expression of Homer family proteins in the developing mouse brain. J. Comp. Neurol. 473:582-599, 2004

81. Sato, Y., Shiraishi, Y., and Furuichi, T. Cell specificity and efficiency of the Semliki forest virus vector- and adenovirus vector-mediated gene expression in mouse cerebellum. J. Neurosci. Methods 137:111-121, 2004

82. Kakinuma, Y., Saito, F., Osawa, S., Furuichi, T., and Miura, M. A sulfatase regulating the migratory potency of oligodendrocyte progenitor cells through tyrosine phosphorylation of beta-catenin. J. Neurosci. Res. 77:653-661, 2004

83. Yanagida, E., Shoji, S., Hirayama, Y., Yoshikawa, F., Otsu, K., Uematsu, H., Hiraoka, M., Furuichi, T., and Kawano, S. Functional expression of Ca2+ signaling pathways in mouse embryonic stem cells. Cell Calcium 36:135-146, 2004

84. Shiraishi, Y., Mizutani, A., Mikoshiba, K., and Furuichi, T. Coincidence in dendritic clustering and synaptic targeting of homer proteins and NMDA receptor complex proteins NR2B and PSD95 during development of cultured hippocampal neurons. Mol. Cell. Neurosci. 22:188-201, 2003

85. Shiraishi, Y., Mizutani, A., Yuasa, S., Mikoshiba, K., and Furuichi, T. Glutamate-induced declustering of post-synaptic adaptor protein Cupidin (Homer2/vesl-2) in cultured cerebellar granule cells. J. Neurochem. 87:364-376, 2003

86. Uchida, K., Miyauchi, H., Furuichi, T., Michikawa, T., and Mikoshiba, K. Critical regions for activation gating of the inositol 1,4,5-trisphosphate receptor. J. Biol. Chem. 278:16551-16560, 2003

87. Tomomura, M., Hasegawa, Y., Hashikawa, T., Tomomura, A., Yuzaki, M., Furuichi, T., and Yano, R. Differential expression and function of apoptosis-associated tyrosine kinase (AATYK) in the developing mouse brain. Mol. Brain Res. 112:103-112, 2003

88. Bosanac, I., Alattia, J.R., Mal, T.K., Chan, J., Talarico, S., Tong, F.K., Tong, K.I., Yoshikawa, F., Furuichi, T., Iwai, M., Michikawa, T., Mikoshiba, K., and Ikura, M. Structure of the inositol 1,4,5-trisphosphate receptor binding core in complex with its ligand. Nature 420:696-700, 2002 (IF 31.434)

89. Iwasaki, H., Chiba, K., Uchiyama, T., Yoshikawa, F., Suzuki, F., Ikeda, M., Furuichi, T., and Mikoshiba, K. Molecular characterization of the starfish inositol 1,4,5-trisphosphate receptor and its role during oocyte maturation and fertilization. J. Biol. Chem. 277:2763-2772, 2002

90. Uchiyama, T., Yoshikawa, F., Hishida, A., Furuichi, T., and Mikoshiba, K. A novel recombinant hyperaffinity inositol 1,4,5-trisphosphate (IP3) absorbent traps IP3, resulting in specific inhibition of IP3-mediated calcium signaling. J. Biol. Chem. 277:8106-8113, 2002

91. Kagami, Y., and Furuichi, T. Investigation of differentially expressed genes during the development of mouse cerebellum. Gene Expr. Patterns 1:39-59, 2001

92. Shiraishi, Y., Mizutani, A., Bito, H., Fujisawa, K., Narumiya, S., Mikoshiba, K., and Furuichi, T. Cupidin, an isoform of Homer/Vesl, interacts with the actin cytoskeleton and activated Rho family small GTPases and is expressed in developing mouse cerebellar granule cells. J. Neurosci. 19:8389-8400, 1999

93. Michikawa, T., Hirota, J., Kawano, S., Hiraoka, M., Yamada, M., Furuichi, T., and Mikoshiba, K. Calmodulin mediates calcium-dependent inactivation of the cerebellar type 1 inositol 1,4,5-trisphosphate receptor. Neuron 23:799-808, 1999

94. Hirota, J., Furuichi, T., and Mikoshiba, K. Inositol 1,4,5-trisphosphate receptor type 1 is a substrate for Caspase-3 and is cleaved during apoptosis in a Caspase-3-dependent manner. J. Biol. Chem. 274:34433-34437, 1999

95. Baylis, H.A., Furuichi, T., Yoshikawa, F., Mikoshiba, K., and Sattelle, D.B. Inositol 1,4,5-trisphosphate receptors are strongly expressed in the nervous system, pharynx, intestine, gonad and excretory cell of Caenorhabditis elegans and are encoded by a single gene (itr-1). J. Mol. Biol. 294:467-476, 1999

96. Zhu, C.C., Furuichi, T., Mikoshiba, K., and Wojcikiewicz, R.J.H. Inositol 1,4,5-trisphosphate receptor down-regulation is activated directly by inositol 1,4,5-trisphosphate binding. J. Biol. Chem. 274:3476-3484, 1999

97. Yoshikawa, F., Iwasaki, H., Michikawa, T., Furuichi, T., and Mikoshiba, K. Trypsinized cerebellar inositol 1,4,5-trisphosphate receptor: structural and functional coupling of cleaved ligand binding and channel domains. J. Biol. Chem. 274:316-327, 1999

98. Yoshikawa, F., Iwasaki, H., Michikawa, T., Furuichi, T., and Mikoshiba, K. Cooperative formation of the ligand-binding site of the inositol 1,4,5-trisphosphate receptor by two separable domains. J. Biol. Chem. 274:328-334, 1999

99. Yoshikawa, F., Uchiyama, T., Iwasaki, H., Tomomori-Satoh, C., Tanaka, T., Furuichi, T., and Mikoshiba, K. High efficient expression of the functional ligand binding site of the inositol 1,4,5-trisphosphate receptor in Escherichia coli. Biochem. Biophys. Res. Commun. 257:792-797, 1999

100. Natsume, T., Hirota, J., Yohikawa, F., Furuichi, T., and Mikoshiba, K. Real time analysis of interaction between inositol 1,4,5-Trisphosphate receptor type 1 and its ligand. Biochem. Biophys. Res. Commun. 260:527-533, 1999

101. Konishi, Y., Ohkawa, N., Makino, Y., Okubo, H., Kageyama, R., Furuichi, T., Mikoshiba, K., and Tamura, T. Transcriptional regulation of mouse type 1 inositol 1,4,5-trisphosphate receptor gene by NeuroD-related factor. J. Neurochem. 72:1717-1724, 1999

102. Mitsuyama, F., Sawai, T., Carafoli, E., Furuichi, T., and Mikoshiba, K. Microinjection of Ca2+ store-enriched microsome fractions to dividing newt eggs induces extra-cleavage furrows via inositol 1,4,5-trisphosphate-induced Ca2+ release. Dev. Biol. 214:160-167, 1999

103. Hirota, J., Michikawa, T., Natsume, T., Furuichi, T., and Mikoshiba. K. Calmodulin inhibits inositol 1,4,5-trisphosphate-induced calcium release through the purified and reconstituted inositol 1,4,5-trisphosphate receptor type 1. FEBS Lett. 456:322-326, 1999

104. Hitota, J., Baba, M., Matsumoto, M., Furuichi, T., Takatsu, K., and Mikoshiba, K. T-cell-receptor signalling in inositol 1,4,5-trisphosphate receptor (IP3R) type -1-deficient mice: is IP3R type 1 essential for T-cell-receptor signalling? Biochem. J. 333:615-619, 1998

105. Monkawa, T., Hayashi, M., Miyawaki, A., Sugiyama, T., Yamamoto-Hino, M., Hasegawa, M., Furuichi, T., Mikoshiba, K., and Saruta, T. Localization of inositol 1,4,5-trisphosphate receptors in the rat kidney. Kidney Int. 53:296-301, 1998

106. Yamamoto-Hino, M., Miyawaki, A., Segawa, A., Adachi, E., Yamashina, S., Fujimoto, T., Sugiyama, T., Furuichi, T., Hasegawa, M., and Mikoshiba, K. Apical vesicles bearing inositol 1,4,5-trisphosphate receptors in the Ca2+ initiation site of ductal epithelium of submandibular gland. J. Cell Biol. 141:135-142, 1998

107. Morikawa, K., Ohbayashi, T., Nakagawa M., Konishi, Y., Makino, Y., Yamada, M., Miyawaki, A., Furuichi, T., Mikoshiba, K., and Tamura, T. Transcriptional initiation sites and promoter structure of the mouse type 2 inositol 1,4,5-trisphosphate receptor gene. Gene 196:181-185, 1997

108. Konishi, Y., Kobayashi, Y., Kishimoto, T., Makino Y., Miyawaki, A., Furuichi, T., Okano, H., Mikoshiba, K., and Tamura, T. Demonstration of an E-box and its CNS-related binding factors for transcriptional regulation of the mouse type 1 inositol 1,4,5-trisphosphate receptor gene. J. Neurochem. 69:476-484, 1997

109. Sayers, L.G., Miyawaki, A., Muto, A., Takeshita, H., Yamamoto, A., Michikawa, T., Furuichi, T., and Mikoshiba, K. Intracellular targeting and homotetramer formation of a truncated inositol 1,4,5-trisphosphate receptor-green fluorescent protein chimera in Xenopus laevis oocytes: evidence for the involvement of the transmembrane spanning domain in endoplasmic reticulum targeting and homotetramer complex formation. Biochem. J. 323:273-280, 1997

110. Yoneshima, H., Miyawaki, A., Michikawa, T., Furuichi, T., and Mikoshiba, K. Ca2+ differentially regulates the ligand-affinity states of type 1 and type 3 inositol 1,4,5-trisphosphate receptors. Biochem. J. 322:591-596, 1997

111. el-Daher, S.S., Eigenthaler, M., Walter, U., Furuichi, T., Miyawaki, A., Mikoshiba, K., Kakkar, V.V., and Authi, K.S. Distribution and activation of cAMP- and cGMP-dependent protein kinases in highly purified human platelet plasma and intracellular membranes. Thrombosis and Haemostasis 76:1063-1071, 1996

112. Yamada, H., Yamamoto, A., Yodozawa, S., Kozaki, S., Takahashi, M., Morita, M., Michibata, H., Furuichi, T., Mikoshiba, K., and Moriyama, Y. Microvesicle-mediated exocytosis of glutamate is a novel paracrine-like chemical transduction mechanism and inhibits melatonin secretion in rat pinealocytes. J. Pineal Res. 21:175-191, 1996

113. Yoshikawa, F., Morita, M., Monkawa, T., Michikawa, T., Furuichi, T., and Mikoshiba, K. Mutational analysis of the ligand binding site of the inositol 1,4,5-trisphosphate receptor. J. Biol. Chem. 271:18277-18284, 1996

114. Li, M., Miyawaki, A., Yamamoto-Hino, M., Yasutomi, D., Furuichi, T., Hasegawa, M., and Mikoshiba, K. Differential cellular expression of three types of inositol 1,4,5-trisphosphate receptor in rat gastrointestinal epithelium. Biomed. Res. 17:45-51, 1996

115. Furutama, D., Shimoda, K., Yoshikawa, S., Miyawaki, A., Furuichi, T., and Mikoshiba, K.Functional expression of the type 1 inositol 1,4,5-trisphosphate receptor promoter-lacZ fusion gene in transgenic mice. J. Neurochem. 66:1793-1801, 1996

116. Matsumoto, M., Nakagawa, T., Inoue, T., Nagara, E., Tanaka, K., Takano, H., Minowa, O., Kuno, J., Sakakibara, S., Yamada, M., Yoneshima, H., Miyawaki, A., Fukuuchi, Y., Furuichi, T., Okano, H., Mikoshiba, K., and Noda, T. Ataxia and epileptic seizures in mice lacking type 1 inositol 1,4,5-trisphosphtate receptor. Nature 379:168-171, 1996

117. Hirota, J., Michikawa, T., Miyawaki, A., Furuichi, T., Okura, I., and Mikoshiba, K. Kinetics of calcium release by immunoaffinity-purified inositol 1,4,5-trisphosphate receptor in reconstituted lipid vesicles. J. Biol. Chem. 270:19046-19051, 1995

118. Hirota, J., Michikawa, T., Miyawaki, A., Takahashi, M., Takazawa, K., Okura, I., Furuichi, T., and Mikoshiba, K. Adenophostin-mediated quantal Ca2+ release in the purified and reconstituted inositol 1,4,5-trisphosphate receptor type 1. FEBS Lett. 368:248-252, 1995

119. Yamada, M., Miyawaki, A., Saito, K., Nakajima, T., Yamamoto-Hino, M., Ryo, Y., Furuichi, T., and Mikoshiba, K. The calmodulin-binding domain in the mouse type 1 inositol 1,4,5-trisphosphate receptor. Biochem. J. 308:83-88, 1995

120. Monkawa, T., Miyawaki, A., Sugiyama, T., Yoneshima, H., Yamamoto-Hino, M., Furuichi, T., Saruta, T., Hasegawa, M., and Mikoshiba, K. Heterotetrameric complex formation of inositol 1,4,5-trisphosphate receptor subunits. J. Biol. Chem. 270:14700-14704, 1995

121. Fujino, I., Yamada, N., Miyawaki, A., Hasegawa, M., Furuichi, T., and Mikoshiba, K. Differential expression of type 2 and type 3 inositol 1,4,5-trisphosphate receptor mRNAs in various mouse tissues: in situ hybridization study. Cell Tissue Res. 280:201-210, 1995

122. Yamamoto-Hino, M., Miyawaki, A., Kawano, H., Sugiyama, T., Furuichi, T., Hasegawa, M., and Mikoshiba, K. Immunohistochemical study of inositol 1,4,5-trisphosphate receptor type 3 in rat central nervous system. NeuroRep. 6:273-276, 1995

123. Wojcikiewicz, R.J.H., Furuichi, T., Nakade, S., Mikoshiba, K., and Nahorski, S.R. Muscarinic receptor activation down-regulates the type I inositol 1,4,5-trisphosphate receptor by accelerating its degradation. J. Biol. Chem. 269:7963-7969, 1994

124. Wakamori, M., Niidome, T., Furutama, D., Furuichi, T., Mikoshiba, K., Fujita, Y., Tanaka, I., Katayama, K., Yatani, A., Schwartz, A., and Mori, Y. Distinctive functional properties of the neuronal BII (class E) calcium channel. Recept. Channels 2:303-314, 1994

125. Aruga, J., Yokota, N., Hashimoto, M., Furuichi, T., Fukuda, M., and Mikoshiba, K. A novel zinc finger protein, Zic, is involved in neurogenesis, especially in the cell lineage of cerebellar granule cells. J. Neurochem. 63:1880-1890, 1994

126. Yamada, N., Makino, Y., Clark, R.A., Pearson, D.W., Mattei, M.G., Guenet, J.L., Ohama, E., Fujino, I., Miyawaki, A., Furuichi, T., and Mikoshiba, K. Human inositol 1,4,5-trisphosphate type 1 receptor, InsP3R1: structure, function, regulation of expression and chromosomal localization. Biochem. J. 302:781-790, 1994

127. Sugiyama, T., Yamamoto-Hino, M., Miyawaki, A., Furuichi, T., Mikoshiba, K., and Hasegawa, M. Subtypes of inositol 1,4,5-trisphosphate receptor in human hematopoietic cell lines: dynamic aspects of their cell-type specific expression. FEBS Lett. 349:191-196, 1994

128. Yamamoto-Hino, M., Sugiyama, T., Hikichi K., Mattei, M.G., Hasegawa, K., Sekine S., Sakurada, K., Miyawaki, A., Furuichi, T., Hasegawa, M., and Mikoshiba, K. Cloning and characterization of human type 2 and type 3 inositol 1,4,5-trisphosphate receptors. Recept. Channels 2:9-22, 1994

129. Michikawa, T., Hamanaka, H., Otsu, H., Yamamoto, A., Miyawaki, A., Furuichi, T., Tashiro, Y., and Mikoshiba, K. Transmembrane topology and sites of N-glycosylation of inositol 1,4,5-trisphosphate receptor. J. Biol. Chem. 269:9184-9189, 1994

130. Yuzaki, M., Furuichi, T., Mikoshiba, K., and Kagawa, Y. A stimulus paradigm inducing long-term desensitization of AMPA receptors evokes a specific increase in BDNF mRNA in cerebellar slices. Learning and Memory 1:230-242, 1994

131. Furuichi, T., Furutama, D., Hakamata, Y., Nakai, J., Takeshima, H., and Mikoshiba, K. Multiple types of ryanodine receptors/Ca2+ release channels are differentially expressed in rabbit brain. J. Neurosci. 14:4794-4805, 1994

132. Ryo, Y., Miyawaki, A., Furuichi, T., and Mikoshiba, K. Expression of the metabotropic glutamate receptor mGluR1 alpha and the ionotropic glutamate receptor GluR1 in the brain during the postnatal development of normal mouse and in the cerebellum from mutant mice. J. Neurosci. Res. 32:19-32, 1993

133. Kume, S., Muto, A., Aruga, J., Nakagawa, T., Furuichi, T., Nakade, S., Okano, H., and Mikoshiba, K. The Xenopus IP3 receptor: Structure, function, and localization in oocytes and eggs. Cell 73:555-570, 1993

134. Yoshikawa, Y., Miyamoto, I., Aruga, J., Furuichi, T., Okano, H., and Mikoshiba, K. Isolation of a Drosophila gene encoding a head-specific guanylyl cyclase. J. Neurochem. 60:1570-1573, 1993

135. Fujita, Y., Mynlieff, M., Dirksen, R.T., Kim, M.S., Niidome, T., Nakai, J., Friedrich, T., Iwabe, N., Miyata, T., Furuichi, T., Furutama, D., Mikoshiba, K., Mori, Y., and Beam, K.G. Primary structure and functional expression of the omega-conotoxin-sensitive N-type calcium channel from rabbit brain. Neuron 10:585-598, 1993

136. Furuichi, T., Simon-Chazottes, D., Fujino, I., Yamada, N., Hasegawa, M., Miyawaki, A., Yoshikawa, S., Guenet, J.L., and Mikoshiba, K. Widespread expression of inositol 1,4,5-trisphosphate receptor type 1 gene (Insp3r1) in the mouse central nervous system. Recept. Channels 1:11-24, 1993

137. Yoshikawa, S., Tanimura, T., Miyawaki, A., Nakanura, M., Yuzaki, M., Furuichi, T., and Mikoshiba, K. Molecular cloning and characterization of the inositol 1,4,5-trisphosphate receptor in Drosophila melanogaster. J. Biol. Chem. 267:16613-16619, 1992

138. Miyawaki, A., Furuichi, T., Ryou, Y., Yoshikawa, S., Nakagawa, T., Saitoh, T., and Mikoshiba, K. Structure-function relationships of the mouse inositol 1,4,5-trisphosphate receptor. Proc. Natl. Acad. Sci. U.S.A. 88: 4911-4915, 1991

139. Nakagawa, T., Okano, H., Furuichi, T., Aruga, J., and Mikoshiba, K. The subtypes of the mouse inositol 1,4,5-trisphosphate receptor are expressed in a tissue-specific and developmentally specific manner. Proc. Natl. Acad. Sci. U.S.A. 88:6244-6248, 1991

140. Mori, Y., Friedrich, T., Kim, M.S., Mikami, A., Nakai, J., Ruth, P., Bosse, E., Hofmann, F., Flockerzi, V., Furuichi, T., Mikoshiba, K., Imoto, K., Tanabe, T., and Numa, S. Primary structure and functional expression from complementary DNA of a brain calcium channel. Nature 350:398-402, 1991

141. Nakahira, K., Ikenaka, K., Wada, K., Tamura, T., Furuichi, T., and Mikoshiba, K. Structure of the 68-kDa neurofilament gene and regulation of its expression. J. Biol. Chem. 265:19786-19791, 1990

142. Miyawaki, A., Furuichi, T., Maeda, N., and Mikoshiba, K. Expressed cerebellar-type inositol 1,4,5-trisphosphate receptor, P400, has calcium release activity in a fibroblast L cell line. Neuron 5:11-18, 1990

143. Inoue, T., Tamura, T., Furuichi, T., and Mikoshiba, K. Isolation of complementary DNAs encoding a cerebellum-enriched nuclear factor I family that activates transcription from the mouse myelin basic protein promoter. J. Biol. Chem. 265:19065-19070, 1990

144. Furuichi, T., Shiota, C., and Mikoshiba, K. Distribution of inositol 1,4,5-trisphosphate receptor mRNA in mouse tissues. FEBS Lett. 267:85-88, 1990

145. Furuichi, T., Yoshikawa, S., and Mikoshiba, K. Nucleotide sequence of cDNA encoding P400 protein in the mouse cerebellum. Nucleic Acids Res. 17:5385-5386, 1989

146. Furuichi, T., Yoshikawa, S., Miyawaki, A., Wada, K., Maeda, N., and Mikoshiba, K. Primary structure and functional expression of the inositol 1,4,5-trisphosphate-binding protein P400. Nature 342:32-38, 1989

147. Ikenaka, K., Furuichi, T., Iwasaki, Y., Moriguchi, A., Okano, H., and Mikoshiba, K. Myelin proteolipid protein gene structure and its regulation of expression in normal and jimpy mutant mice. J. Mol. Biol. 199:587-596, 1988

148. Dhundale, A., Furuichi, T., Inouye, M., and Inouye, S. Mutations that affect production of branched RNA-linked msDNA in Myxococcus xanthus. J. Bacteriol. 170:5620-5624, 1988

149. Moriguchi, A., Ikenaka, K., Furuichi, T., Okano, H., Iwasaki, Y., and Mikoshiba, K. The fifth exon of the myelin proteolipid protein-coding gene is not utilized in the brain of jimpy mutant mice. Gene 55:333-337, 1987

150. Dhundale, A., Lampson, B., Furuichi, T., Inouye, M., and Inouye, S. Structure of msDNA from Myxococcus xanthus: evidence for a long, self-annealing RNA precursor for the covalently linked, branched RNA. Cell 51:1105-1112, 1987

151. Furuichi, T., Inouye, S., and Inouye, M. Biosynthesis and structure of stable branched RNA covalently linked to the 5' end of multicopy single-stranded DNA of Stigmatella aurantiaca. Cell 48:55-62, 1987

152. Furuichi, T., Dhundale, A., Inouye, M., and Inouye, S. Branched RNA covalently linked to the 5' end of a single-stranded DNA in Stigmatella aurantiaca: structure of msDNA. Cell 48:47-53, 1987

153. Komano, T., Kubo, A., Kayanuma, T., Furuichi, T., and Nisioka, T. Highly mobile DNA segment of incI-alpha plasmid R64: a clustered inversion region. J. Bacteriol. 165:94-100, 1986

154. Dhundale, A.R., Furuichi, T., Inouye, S., and Inouye, M. Distribution of multicopy single-stranded DNA among myxobacteria and related species. J. Bacteriol. 164:914-917, 1985

155. Furuichi, T., Inouye, M., and Inouye, S. Novel one-step cloning vector with a transposable element: application to the Myxococcus xanthus genome. J. Bacteriol. 164:270-275, 1985

156. Teintze, M., Thomas, R., Furuichi, T., Inouye, M., and Inouye, S. Two homologous genes coding for spore-specific proteins are expressed at different times during development of Myxococcus xanthus. J. Bacteriol. 163:121-125, 1985

157. Furuichi, T., Komano, T., Inouye, M., and Inouye, S. Functional complementation between the two homologous genes, ops and tps, during differentiation of Myxococcus xanthus. Mol. Gen. Genet. 199:434-439, 1985

158. Yee, T., Furuichi, T., Inouye, S., and Inouye, M. Multicopy single-stranded DNA isolated from a gram-negative bacterium, Myxococcus xanthus. Cell 38:203-209, 1984

159. Komano, T., Furuichi, T., Teintze, M., Inouye, M., and Inouye, S. Effects of deletion of the gene for the development-specific protein S on differentiation in Myxococcus xanthus. J. Bacteriol. 158:1195-1197, 1984

160. Furuichi, T., Komano, T., and Nisioka, T. Physical and genetic analyses of the Inc-I-alpha plasmid R64. J. Bacteriol. 158:997-1004, 1984

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